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Research Senior Scientist, Biologics Expression

Company: Takeda Pharmaceutical
Location: Billerica
Posted on: September 23, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide. Join Takeda as a Research Senior Scientist where you will join an exciting, fast-paced Therapeutic Generation and Screening group focused on using state-of-the-art mammalian expression technology to create novel biologics therapeutics to improve patients' lives in the fields of Oncology, Gastroenterology, Neuroscience, and Rare Diseases. Here, you will independently perform transient mammalian transfections for both higher throughput screening efforts and larger volume transfections and stable cell scale up in wave bags in efforts to advance early therapeutic discovery molecules. You will also be proficient in recombinant DNA techniques and vector design to generate novel biologics. As part of the Global Biologics team, you will report to the Principal Scientist, Therapeutic Generation and Screening, and work with matrixed project teams and interface very closely with members of other therapeutic groups. How you will contribute:

  • Perform higher throughput production of antibodies, bispecifics and protein antigens used to discover and advance novel therapeutics.
  • Experience in expression of small to large scale production of antibodies, bispecifics and protein antigens with significant experience in the use of wave bags is required.
  • Thorough understanding of mammalian cell culture and transfection technologies including electroporation and fermentation principles are a requirement.
  • Extensive experience in molecular biology and reformatting protein/antibody workflows for expression as well as experience in designing engineering solutions (multispecifics and innovative non-antibody fusions) for projects is also required.
  • Evaluate and implement new methods for transient protein expression when appropriate.
  • Experience with expression of multispanning membrane proteins such as GPCRs.
  • Perform data analysis and troubleshooting.
  • Maintain responsibility for routine laboratory instrumentation and supplies.
  • Summarize and communicate results at team meetings and contribute to scientific discussions.
  • Strong experience in molecular biology and vector manipulation and molecular biology software (SnapGene and Genious Prime and Biologics).
  • Proficient at tracking and entering data in LIMS systems (preferably GeneData Biologics) and maintaining a detailed electronic notebook. What you bring to Takeda:
    • BS with 11+ years experience, MS with 9+ years experience, or Ph.D. with 3+ years of experience in Molecular Biology, Mammalian Cell Culture, Structural Biology, or Protein Engineering.
    • Previous hands on experience with mammalian cell culture techniques is required.
    • Experience with mammalian cell culture techniques using fermenters or wave bags.
    • Experience with molecular biology techniques.
    • Understanding of mammalian cell fermentation needs and possibilities for improvement.
    • Previous experience with expression of membrane proteins.
    • Experience managing Co-ops, Research Associates and training fellow scientists.
    • Experience with existing technologies for mammalian protein production and an ability to create novel technologies when necessary.
    • Excellent organizational skills and attention to details.
    • Self-motivated, curious, independent and eager to learn.
    • Effective verbal and written communication as well as strong interpersonal skills required. What Takeda can offer you:
      • Comprehensive Healthcare: Medical, Dental, and Vision
      • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach Programs and company match of charitable contributions
      • Family Planning Support
      • Flexible Work Paths
      • Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Keywords: Takeda Pharmaceutical, Billerica , Research Senior Scientist, Biologics Expression, Other , Billerica, Massachusetts

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